Matrixyl ® — anti-age complex

Matrixyl ® — one of the most famous anti-aging active ingredients with proven effectiveness.

Matrixyl ® by Sederma

The French company Sederma (Croda International Plc), which develops a unique range of active cosmetic ingredients with proven efficiency, meeting the needs of consumers and the desire of manufacturers to use innovative products for the public, has launched the Matrixyl® line. All over the world, this name is synonymous with efficiency and reliability in the fight against the signs of aging. The Matrixyl® line has been honored with the 25 Years of Innovation award for the product that has made the greatest impact on the personal care ingredients market over the past quarter century.

Matrikin: complicated, but effective

Matrikin is a technical term coined by Professor McWart to describe oligopeptides and protein fragments that are formed during the breakdown of macromolecules (first phase). Some of the fragments thus formed have stimulating and signaling properties, initiating the process of tissue matrix restoration, hence the name. These peptide fragments are involved in wound healing.

Sederma is the first company to develop extracellular matrix-derived matrikin peptides that are exact replicas of the skin's natural matrixins. They act from the inside out as messengers of the cells, able to regulate the skin regeneration chain of events, providing long-term anti-aging of the skin. Matrix peptides trigger intracellular metabolism, resulting in tissue repair, wound healing, and stimulation of macromolecule synthesis.


Matrixyl® synthe'6®

Collagen or hyaluronic acid injections are considered effective treatments for wrinkles, but not many women take it. Most prefer less radical ways, but even they have to be efficient and accurate.

Matrixyl ® synthe'6 ® — is a representative of the Matrixyl ® line, who will help in solving this problem. The complex makes the skin noticeably smoother and more elastic, filling in wrinkles from the inside both on the forehead and in the area of "crow's feet".


  • Glycerin.
  • Water (Aqua).
  • Hydroxypropyl Cyclodextrin.
  • Palmitoyl Tripeptide-38.

Proven Efficiency

Synthesis of 6 main skin components

Matrixyl ® synthe'6 ®, with its matrix-like effect, stimulates the synthesis of 6 main structural components of the skin matrix and dermo-epidermal junction: collagen I, collagen III, collagen IV, fibronectin, hyaluronic acid and laminin.

Research conducted with 2% Matrixyl ® synthe'6 ®:

Method % of diversity Significance
• Collagen I
Immunolabeling on human fibroblasts +105% Very high, p<0,01
Immunolabeling on skin explants (application 2 times per day for 5 days) +37,5% Very high, p<0,01
• Collagen III
Immunolabeling on human fibroblasts 104% Very high, p<0,01
• Collagen IV
ELISA method on human fibroblasts +42% Very high, p<0,01
• HSP47*
*the HSP47 chaperone protein is needed for collagen maturation, binds to collagen types from I to V.
Western Blot on human fibroblasts +123% Very high, p<0,01
• Hyaluronic acid
ELISA method on human keratinocytes +174% Very high, p<0,01
• Fibronectin
ELISA method on human fibroblasts +59% Very high, p<0,01
• Laminin-5
Immunolabeling on skin explants +15% High, p<0,05
ELISA method on human keratinocytes +75% Very high, p<0,01

Anti-wrinkle efficiency

The research involved 25 women in age from 42 to 70 years. Twice a day for 2 months they used 2% Matrixyl ® synthe'6 ® on one side of the face and a placebo on the other half. The FOITS method, which was used to measure the results on the forehead area, as well as the Silfto® method in conjunction with FOITS in the crow's feet area, proved the cream's high effectiveness. Matrixyl ® synthe'6 ® restructures and smoothes the skin like a lifting.

Matrixyl® synthe'6® in L’Adeleide products

The company "Adelaide" took into account the achievements and the latest developments in the field of cosmetic active ingredients anti-age and released a line of hyaluronic creams with the Matrixyl® synthe'6® complex: day cream, night cream and a product for the care of the skin around the eyes.

Active components:

  • Low molecular weight HA - a component for hydration, rejuvenation and UV protection, acts on the deep layers of the skin.
  • Medium molecular HA - a tool for combating microdamage of the skin, improving lymph drainage and elimination of toxins.
  • High molecular weight HA provides an instant lifting effect, smoothing and tightening the skin.
  • The peptide complex Matrixyl ® synthe'6 ® fills wrinkles with guaranteed action in three directions: quantity, length, depth.

The line is designed for complex daily care and is suitable for all skin types. For ease of use, a cream spatula is included.

В статье использованы материалы:
1.с сайта производителя линейки Matrixyl ® (Sederma, Croda International Plc):;
2.с сайта Matrixyl inside: